Prep Oven & Sheet Pan: Preheat your oven to 425°F (220°C). Position an oven rack in the center. Line a large rimmed 18x13-inch half-sheet baking pan with parchment paper or heavy-duty foil for effortless cleanup.
Slice Chicken & Vegetables: Slice chicken breasts across the grain into uniform 1/2-inch strips. Slice bell peppers and red onion into matching 1/3-inch wide strips so they cook evenly together.
Whisk Fajita Spice Blend: In a small bowl, combine chili powder, ground cumin, garlic powder, smoked paprika, fine sea salt, black pepper, and Mexican oregano.
Season & Toss on Sheet Pan: Place the sliced chicken, peppers, and onions directly onto the prepared sheet pan. Drizzle with 3 tablespoons of olive oil and sprinkle the spice blend evenly across everything. Use tongs or your hands to toss thoroughly until every strip is glossy and well coated.
Spread in Single Layer: Spread the ingredients out into an even, single layer across the pan. Avoid overlapping piles so the veggies roast with blistered charred edges instead of steaming.
Roast to Sizzling: Bake at 425°F for 20 to 22 minutes, flipping once halfway through with a spatula, until the chicken reaches 165°F (74°C) internally and the pepper edges are gorgeously blistered.
Whisk Lime Crema: While the sheet pan roasts, whisk sour cream (or Greek yogurt), 1 tablespoon fresh lime juice, lime zest, 1 tablespoon minced cilantro, and a tiny pinch of salt in a small bowl until smooth and silky.
Warm Tortillas & Serve: Warm tortillas in a dry skillet for 30 seconds per side. Pile sizzling chicken fajitas onto warm tortillas, drizzle generously with lime crema, and garnish with remaining fresh cilantro and lime wedges.